Flatbed Annie & Sweetie Pie: Lady Truckers(1979)

This engaging made-for-television movie follows the adventures of Ginny "Sweetie Pie" LaRosa (Kim Darby), who needs money after her trucker husband, Jack (Fred Willard), is shot by hijackers. Fortunately, she finds a partner in Flatbed Annie (Annie Potts), a freewheelin' driver. The women form an unlikely but profitable friendship while fending off the repo man who wants the truck and the criminals who are after the cocaine hidden in it.