Zach puts Michael Cera, the Superbad and Juno star in the hot seat for this special Comedy Death-Ray interview.

Zach interviews talk show host Jimmy Kimmel.

Zach interviews Jon Hamm of AMC's Mad Men.

Zach interviews Natalie Portman and her dog, Whiz.

Zach chats with Bradley Cooper, star of "The Hangover."

Zach has a chat with Charlize Theron, Academy Award winner and star of The Road.

Zach sits down with the host of the Tonight Show, Conan O'Brien, and his announcer, Andy Richter.

Zach sits down with Ben Stiller, star of the 'Meet the Fockers' series as well as the new movie, Greenberg.

Zach sits down with Steve Carell from "The Office" and they quite possibly discuss "Dinner for Schmucks".

Sean Penn sits down with Zach's twin brother, Seth Galifianakis.

Zach sits down with Bruce Willis; one of the stars of the new movie Red, to talk about the 80s and some of the presti...

Zach sits down with Tila Tequila who may become his new best friend and also welcomes another guest on the show who s...

Zach sits down with Will Ferrell, the star of Everything Must Go, Anchorman and Old School, to talk about lunch, danc...

Zach Galifianakis sits down with Jennifer Lawrence, Anne Hathaway, Christoph Waltz, Naomi Watts & Amy Adams who are g...

Zach Galifianakis sits down with Bradley Cooper, Jessica Chastain, Sally Field and another special guest from Lincoln.

Zach Galifianakis sits down with James Franco to have a normal, everyday, run of the mill interview.

Zach Galifianakis sits down with Justin Bieber for an interview no one will ever forget.

President Barack Obama sits down with Zach Galifianakis for his most memorable interview yet.

Brad Pitt sits down with Zach Galifianakis for his second most memorable interview yet.

Hillary Clinton sits down with Zach Galifianakis for her most memorable interview yet.

Jerry Seinfeld and Cardi B sit down with Zach Galifianakis for an interview without coffee, cars, or money moves.